40 principal scientist jobs found

Merck Job Description The Discovery Pharmaceutical Sciences (DPS) group based in South San Francisco, CA is seeking an Principal Scientist with small molecule and peptide experience. DPS is a multi-disciplinary research group that provides drug delivery, solid state crystal form characterization, pre-formulation and formulation support and small molecule and biologics developability assessments at the development and drug discovery interface. Our team is responsible for the characterization of pre-clinical drug candidates' physicochemical properties. We aim to work with partner groups to select candidates with optimal development properties while balancing all other key therapeutic properties. Our research also covers identification of preclinical formulations for pharmacology and toxicology studies and ideally for FIH across a variety of administration routes and modalities (small molecules, peptides, proteins, oligonucleotides, and biologics). In this exciting role,...

Merck Job Description The Discovery Pharmaceutical Sciences (DPS) group based in South San Francisco, CA is seeking an Principal Scientist with small molecule and peptide experience. DPS is a multi-disciplinary research group that provides drug delivery, solid state crystal form characterization, pre-formulation and formulation support and small molecule and biologics developability assessments at the development and drug discovery interface. Our team is responsible for the characterization of pre-clinical drug candidates' physicochemical properties. We aim to work with partner groups to select candidates with optimal development properties while balancing all other key therapeutic properties. Our research also covers identification of preclinical formulations for pharmacology and toxicology studies and ideally for FIH across a variety of administration routes and modalities (small molecules, peptides, proteins, oligonucleotides, and biologics). In this exciting role,...

CSL CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide. Could you be our next Principal Scientist, Clinical Assay Strategy? The job is in our Waltham MA office. This is a hybrid position and is onsite three days a week. You will report to the Director of Clinical Assay. Position Description Summary: You will part of a specialized non-laboratory based team and provide high level expertise in the area of bioanalytical and biomarker assays to support nonclinical and clinical studies. This role will support the external tactical execution of bioanalytical/biomarker assays to ensure delivery of innovative assays and key data sets to meet the business needs. Broad...

GSK Job Description As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on developing, integrating, and embedding bleeding edge computational methods and predictive in silico models that drive the discovery of new medicines and vaccines. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients. We create a place...

GSK As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on translating biological mechanisms of disease to molecular mechanisms of therapeutics by integrating perturbation data to design new molecules that modulate disease phenotypes. The advancement in de novo design technologies has opened the doors to generate molecules to test biological hypotheses at scale, build up foundational data to predict new perturbation effects, accelerate the validation of disease intervention points, and drive therapeutic discovery campaigns. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to...

GSK As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on translating biological mechanisms of disease to molecular mechanisms of therapeutics by integrating perturbation data to design new molecules that modulate disease phenotypes. The advancement in de novo design technologies has opened the doors to generate molecules to test biological hypotheses at scale, build up foundational data to predict new perturbation effects, accelerate the validation of disease intervention points, and drive therapeutic discovery campaigns. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to...

GSK Job Description As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on developing, integrating, and embedding bleeding edge computational methods and predictive in silico models that drive the discovery of new medicines and vaccines. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients. We create a place...

GSK As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on translating biological mechanisms of disease to molecular mechanisms of therapeutics by integrating perturbation data to design new molecules that modulate disease phenotypes. The advancement in de novo design technologies has opened the doors to generate molecules to test biological hypotheses at scale, build up foundational data to predict new perturbation effects, accelerate the validation of disease intervention points, and drive therapeutic discovery campaigns. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to...

GSK Job Description As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on developing, integrating, and embedding bleeding edge computational methods and predictive in silico models that drive the discovery of new medicines and vaccines. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients. We create a place...

Rich Products Corporation Rich's, also known as Rich Products Corporation, is a family-owned food company dedicated to inspiring possibilities. From cakes and icings to pizza, appetizers and specialty toppings, our products are used in homes, restaurants and bakeries around the world. Beyond great food, our customers also gain insights to help them stay competitive, no matter their size. Our portfolio includes creative solutions geared at helping food industry professionals compete in foodservice, retail, in-store bakery, deli, and prepared foods, among others. Working in 100 locations globally, with annual sales exceeding $4billion, Rich's is a global leader with a focus on everything that family makes possible. Rich's-Infinite Possibilities. One Family. Purpose Statement The Principal Scientist - Dairy is a subject matter expert (SME) within the Global Toppings, Creamers, and Culinary Solutions (TCCS) Center of Excellence (COE), as part of the Research, Innovation, and...

GSK As a lab-based In Vivo Respiratory Principal Scientist in the Complex Models group within the Respiratory, Immunology & Inflammation Biology Unit (RIIBU), you will contribute to the in vivo biology strategy and will lead the design, execution, and reporting of preclinical integrative (in vivo, in vitro and ex vivo) experiments to support therapeutic area teams and drug discovery projects from target validation through to clinical phases You will have the opportunity to work on targets, in vivo models, and integrative, translational biology relevant to respiratory diseases such as COPD and IPF/ILD . Key Accountabilities / Responsibilities: Contribute to the design and lab/vivarium-based execution of in vivo strategies for the respiratory disease area. Contribute to the delivery of Respiratory preclinical efficacy and mechanistic in vivo studies using respiratory models to enable PK/PD and translational biomarker data generation. Lead discussions to ascertain a...

Alkermes, Inc. The Principal Scientist position within Analytical Development provides technical leadership for small molecule analytical methodologies and is a subject matter expert both within and outside the department as part of a growing, dynamic Pharmaceutical Development organization. The Principal Scientist works within the Analytical Development team to characterize drug substance, drug product, impurities, degradants, and metabolites from pre-clinical research through drug development and commercialization. The successful candidate will thrive in a highly collaborative matrix team environment to drive critical decision-making and ensure the successful development of new drugs. Responsibilities Responsibilities: Serve as the primary Analytical Development representative on CMC teams, translate program objectives into phaseappropriate analytical strategies, plans, and timelines. Provide strategic CDMO oversight for analytical activities, which may include product...

Biogen About the Role: Biogen is seeking a highly motivated and experienced Principal Scientist specializing in biotransformation/metabolite identification to join the Drug Metabolism and Pharmacokinetics (DMPK) department. This role is ideal for a technically strong scientist who thrives in a hands-on laboratory environment and enjoys solving complex drug metabolism challenges. The successful candidate will design and execute studies to identify and characterize drug metabolites, oversee some outsourced work, and deliver high-quality data to support drug discovery and development programs. Excellent communication and interpersonal skills are required, along with scientific thinking and problem-solving skills. What You'll Do: Design, execute, and interpret biotransformation studies to characterize drug metabolites in vitro and in vivo. Conduct hands-on laboratory work, including sample preparation, LC-MS/MS, and high-resolution mass spectrometry (HRMS) for metabolite...

CSL CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide. Could you be our next Principal Scientist? The job is in our King of Prussia, PA, Waltham MA, Zurich Switzerland or Maidenhead UK office. This is a hybrid position and is onsite three days a week. You will hold work closely with the CDT Lead and other Clinical Representatives in performing delegated tasks in support of the clinical development program as dictated by therapeutic area/ project needs. Main Responsibilities: 1 Contribute to the scientific development of clinical programs and individual clinical studies in alignment with the clinical development plan within the assigned therapeutic area. 2...

CSL CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide. Could you be our next Principal Scientist? The job is in our King of Prussia, PA, Waltham MA, Zurich Switzerland or Maidenhead UK office. This is a hybrid position and is onsite three days a week. You will hold work closely with the CDT Lead and other Clinical Representatives in performing delegated tasks in support of the clinical development program as dictated by therapeutic area/ project needs. Main Responsibilities: 1 Contribute to the scientific development of clinical programs and individual clinical studies in alignment with the clinical development plan within the assigned therapeutic area. 2...

Merck Job Description Associate Principal Scientist Regulatory Affairs- Oncology At our company, we aspire to be the premier research-intensive biopharmaceutical company. We're at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We use the power of leading-edge science to save and improve lives around the world. Join our team and contribute to our mission of making a difference in the lives of patients globally. Responsibilities: Assisting in Regulatory Agency communications and submissions, including marketing applications, investigational new drug (IND) applications, pediatric plans, and annual or other periodic reports. Implementing strategy to develop Agency background packages and documents associated with regulatory submissions for marketing applications. Communicating with Agencies and attending Agency meetings as needed to assist the global regulatory lead....

Merck Job Description Associate Principal Scientist Regulatory Affairs- Oncology At our company, we aspire to be the premier research-intensive biopharmaceutical company. We're at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We use the power of leading-edge science to save and improve lives around the world. Join our team and contribute to our mission of making a difference in the lives of patients globally. Responsibilities: Assisting in Regulatory Agency communications and submissions, including marketing applications, investigational new drug (IND) applications, pediatric plans, and annual or other periodic reports. Implementing strategy to develop Agency background packages and documents associated with regulatory submissions for marketing applications. Communicating with Agencies and attending Agency meetings as needed to assist the global regulatory lead....

Merck Job Description Associate Principal Scientist Regulatory Affairs- Oncology At our company, we aspire to be the premier research-intensive biopharmaceutical company. We're at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We use the power of leading-edge science to save and improve lives around the world. Join our team and contribute to our mission of making a difference in the lives of patients globally. Responsibilities: Assisting in Regulatory Agency communications and submissions, including marketing applications, investigational new drug (IND) applications, pediatric plans, and annual or other periodic reports. Implementing strategy to develop Agency background packages and documents associated with regulatory submissions for marketing applications. Communicating with Agencies and attending Agency meetings as needed to assist the global regulatory lead....

Merck Job Description Associate Principal Scientist Regulatory Affairs- Oncology At our company, we aspire to be the premier research-intensive biopharmaceutical company. We're at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We use the power of leading-edge science to save and improve lives around the world. Join our team and contribute to our mission of making a difference in the lives of patients globally. Responsibilities: Assisting in Regulatory Agency communications and submissions, including marketing applications, investigational new drug (IND) applications, pediatric plans, and annual or other periodic reports. Implementing strategy to develop Agency background packages and documents associated with regulatory submissions for marketing applications. Communicating with Agencies and attending Agency meetings as needed to assist the global regulatory lead....

Who we are Together, we’re on a mission to make good health more affordable and accessible, to help millions around the world enjoy healthier lives. It’s a mission that bonds our people across nearly 60 countries and a rich, diverse variety of nationalities and backgrounds. Working here means working with the world’s leading manufacturer of generic medicines, and the proud producer of many of the products on the World Health Organization’s Essential Medicines List. Today, at least 200 million people around the world take one of our medicines every single day. An amazing number, but we’re always looking for new ways to continue making a difference, and new people to make a difference with. The opportunity The Clinical Trial Physician (CTP), Director, sits within Clinical Development and is responsible for contributing to the design and implementation of the clinical development plan, working closely with Disease Area Head, Clinical Development Lead, Clinical Scientist. and...