Postdoctoral Research Fellow – Glycosylation of Enzymes and Therapeutic Entities
Rahway, NJ, US
Requisition ID: POS000274
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
Be a part of the legacy: MRL Postdoctoral Research Fellow Program.
The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
As a postdoctoral fellow in Analytical Enabling Technologies, you will work with a highly collaborative and cross-disciplinary team of scientists across Merck Research Laboratories. The position will be based at the Rahway, NJ site. The postdoctoral fellow will have the opportunity to conceive of and carry out research into protein glycosylation, including strategies to control glycan structure at the single-monosaccharide level and study the effect of altered glycosylation on activity and stability of glycoproteins. The laboratory tools used in this research will include glycosylation enzymes, liquid chromatography, high resolution mass spectrometry, light scattering, circular dichroism, enzyme activity/protein binding assays, and other tools for biophysical characterization. The focus will be on 1) developing a platform for fundamental control of protein glycosylation and 2) using the platform to study altered glycosylation on enzymes and therapeutic proteins.
Responsibilities include but are not limited to:
Developing an enzymatic platform to control protein glycosylation.
Characterizing altered glycosylation with a suite of bioanalytical measurement strategies.
Probing the impact of altered glycosylation on protein higher order structure, stability and in vitro activity.
Education Minimum Requirement:
A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019.
Required Experience and Skills:
Track record of driving scientific publication.
High Resolution Mass Spectrometry – MALDI, ESI.
Liquid Chromatography – HILIC, Reversed-phase, Ion Exchange, Size Exclusion.
Glycan MS data interpretation.
Enzymatic digestion of proteins.
Preferred Experience and Skills:
Protein MS data interpretation (top-down and bottom-up).
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.
If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to email@example.com.
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.
For more information about personal rights under Equal Employment Opportunity, visit:
Merck Careers Our work is someone's hope. Join us. At Merck, we believe in putting patients first in all we do. And we recognize that our employees are our single greatest asset in achieving this mission. Top 5 reasons our people are committed to working at Merck:
Quality of co-workers
Ethical standards and values
Compensation and benefits
At Merck, we have approximately 700 employees with military backgrounds working in 26 US locations. in areas such as Research & Development, Information Technology, Manufacturing, Finance, Sales & Marketing, Legal, Site Services, Human Resources and Six Sigma. We value the experience and technical knowledge that these individuals bring to our organization, in addition to their dedication, discipline, strong leadership skills and training.
Merck offers opportunities in various areas of our company for individuals with military experience. Merck has many employees with military backgrounds who work at several of our U.S. locations. We value their experience and technical knowledge, as well as their dedication, discipline, strong leadership skills and training.